【作者】 刘娜; 安金斗; 冯嵩; 葛微; 陈晓光;
【Author】 LIU Na,AN Jin-dou,FENG Song,GE wei,CHEN Xiao-guang(Department of Pediatrics,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China)
【机构】 郑州大学第一附属医院儿科;
【摘要】 目的采用不同剂量野百合碱(monocrota line,MCT)诱导SD幼鼠右心衰竭模型,探讨适合的右心衰竭模型制作方法。方法清洁级SD雄性幼鼠125只,随机分为G0、G1、G2、G3、G4组,每组各25只SD幼鼠。G1~G4组幼鼠分别一次性腹腔注射MCT 30、40、50、60 mg/kg,诱导制作右心衰竭动物模型;G0组为对照组,给予生理盐水腹腔注射。腹腔注射后每2周1次,采用彩色多普勒超声仪测SD幼鼠右心室横径、三尖瓣反流速度、肺动脉压、射血分数(EF值)、缩短分数(FS值),共检测6周,4次;随后处死SD幼鼠,取心脏、肺组织病理切片对比观察。结果 G0组SD幼鼠无死亡,G1、G2、G3组SD幼鼠的死亡率远远低于G4组。各组SD幼鼠右心室横径逐渐增大,G1~G4组较G0组更明显(P<0.01);G0组SD幼鼠各时期的三尖瓣反流速度、肺动脉压无明显改变,而G1~G4组逐渐增高(P<0.01)。G1组SD幼鼠肺动脉仅出现轻度新生内膜病变,心脏组织病理切片无明显改变;G2组SD幼鼠肺动脉可见较明显新生内膜病变,心脏组织病理切片可见明显炎性细胞浸润;G3、G4组SD幼鼠肺组织... 更多还原
【Abstract】 Objective To establish right ventricular failure model by using different doses of MCT in young SD rats and to explore the optimal method for model establishment.Methods One hundred and twenty five SPF Sprague Dawley male rats were randomly divided into 5 groups(G0-G4)and each group had 25 rats.Different doses of monocrotaline of 30 mg/kg,40 mg/kg,50 mg/kg and 60 mg/kg were given to rats in Group 1 to 4 through intraperitoneal injection respectively in order to establish the model of right ventr... 更多还原 【关键词】 野百合碱; 肺动脉高压; 右心衰竭; 大鼠; 【Key words】 monocrotaline; pulmonary arterial hypertension; right ventricular failure; rat;
【分类号】R285.5
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