【摘要】 已证实,高危型人乳头瘤病毒(HPV)持续性感染是宫颈癌发生的必要条件,但免疫功能正常的感染者,大部分HPV感染会在几个月内自发清除,所以了解影响HPV清除和持续的相关因素及免疫系统在此过程中的作用十分重要。由于HPV感染主要发生在女性下生殖道局部,因此局部微环境对HPV感染结局发挥着重要作用。近年研究发现,一氧化氮(NO)是慢性感染致肿瘤形成微环境中的关键组分,且HPV感染、吸烟、多产和炎症等因素均可诱导宫颈局部产生NO,参与癌变过程。 更多还原

【Abstract】 Although persistent infection with an high-risk human papilloma virus(HPV)is thought to be necessary for most cervical tumorigenesis,most infections have been shown to regress spontaneously under an effective immune response,often within a few months.So understanding the factors that affect the balance between viral persistence and viral clearance and the role of the immune system in these processes is important.As HPV infection happens in the local of female lower genital tract,the local immune... 更多还原