【摘要】 神经生长因子(nerve growth factor,NGF)是神经营养因子家族的一种多肽激素,除能促进神经纤维的生长外,还可以通过自分泌和旁分泌的方式作用于某些特定类型的肿瘤组织,影响其发生、发展和转移。在卵巢癌中,NGF通过与其受体TrkA和p75NTR结合而促进肿瘤供给血管的生成,影响细胞因子的水平,在卵巢癌的发生、发展、侵袭和转移中发挥着不可忽略的作用。充分认识NGF的作用机制,将为其在肿瘤早期诊断、治疗及判定预后方面开辟新领域。 更多还原

【Abstract】 Nerve growth factor(NGF)is a poly-peptide hormone of neurotrophin family.It can stimulate the growth of nerve fibers,besides,it also has the impact on certain kinds of tumor by autocrine and paracrine secretion,and result in the modulation of tumor generation,development and metastasis.Regarding the ovarian cancer,after bind to its receptor TrkA and p75,NGF can enhance the formation of cancer’s supplemental vessels,influence the level of cytokine,thereby it will play an important role in the dev... 更多还原