| 基于PD-PK的中药日服次数合理性评价模式商建 |
| Evaluation pattern for rationality of daily administration times of Chinese materia medica based on pharmacodynamics-pharmacokinetics |
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| 中文关键词: 中药用法 日服次数 药效学-药动学（PD-PK） 临床疗效 评价模式 |
| 英文关键词:usage of Chinese materia medica daily administration times pharmacodynamics-pharmacokinetics (PD-PK) clinical efficacy evaluation pattern |
| 基金项目:国家自然科学基金资助项目（81073069） |
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| 中文摘要: |
| 中药“用法”是关乎中药临床用药安全有效的关键科学问题，日服次数是中药“用法”的主要事项和内容之一，直接关系临床疗效，然而针对日服次数合理性的研究几乎是空白的。为了寻求中药日服次数研究的新突破，在回顾性研究和前瞻性分析的基础上，首次提出“基于药效动力学-药动学（PD-PK）的中药日服次数合理性评价模式”的研究设想，以期为科学确定中药日服次数、提高临床疗效提供具有原创性和实用性的研究思路和方法。 |
| 英文摘要: |
| The usage of Chinese materia medica (CMM) is a key scientific problem on its safety and efficacy in clinical application. The daily administration time is one of the main issues and contents of CMM usage, which is directly related to the clinical efficacy. But, it is hardly to find the research aiming at the rationality of daily administration times of CMM. To achieve new breakthrough in research on daily administration times of CMM, one research presumption is put forward for the first time and it is the evaluation pattern for the rationality of daily administration times of CMM based on pharmacodynamics-pharmacokinetics. The further purpose is to supply innovative and practical research thought and method for scientifically confirming the daily administration times of CMM and enhancing its clinical efficacy. |
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