【摘要】 目的观察新风胶囊(Xinfeng Capsules,XFC)对佐剂性关节炎(adjuvant arthritis,AA)大鼠心功能及血清、心肌脑利钠肽(brain natriuretic peptide,BNP)影响。方法将60只大鼠随机分为正常对照组、模型对照组、甲氨喋呤(methopterin,MTX)组、雷公藤多苷片(Tripterygium glucosides Tablet,TGT)组和XFC组,每组12只,除正常对照组外,分别对其余各组大鼠右后足跖皮内注射弗氏完全佐剂致炎,致炎后第19天开始给药。正常对照组及模型对照组均给予生理盐水,其余3组分别给予MTX、TGT、XFC。观察各组大鼠足跖肿胀度、关节炎指数(arthritis index,AI)、心功能、血清BNP水平及心肌BNP mRNA表达的变化。结果①与正常对照组比较,模型对照组心率(heart rate,HR)、心脏指数(heart index,HI)、左室收缩期压(left ventricular systolic pressure,LVSP)、左室舒张期末压(left ventricular end-diast... 更多还原

【Abstract】 Objective To observe the effects of Xinfeng Capsules(XFC),a traditional Chinese prescription for invigorating spleen-qi,dissipating dampness and removing obstacles from collaterals,on heart function and serum and myocardial brain natriuretic peptides(BNP) in rats with adjuvant arthritis(AA).Methods Sixty rats were averagely randomized into control group,model control group,methotrexate(MTX) treated group,Tripterygium glycosides Tablet(TGT) treated group,and XFC treated group.Except for rats in n... 更多还原