广西莪术的化学成分研究(英文) Chemical Constituents from the Rhizomes of Curcuma kwangsiensis
中国天然药物 , Chinese Journal of Natural Medicines, 编辑部邮箱 , 2011年05期 【作者】 李军; 刘越; 李建强; 陈丽霞; 赵锋; 邱峰;
【Author】 LI Jun1,2,LIU Yue1,2,LI Jian-Qiang1,2,CHEN Li-Xia1,2,ZHAO Feng 3,QIU Feng1,2 1School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;2Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China;3School of Pharmacy,Yantai University,Yantai 264005,China
【机构】 沈阳药科大学中药学院; 沈阳药科大学基于靶点的药物设计与研究教育部重点实验室; 烟台大学药学院;
【摘要】 目的:对广西莪术(Curcuma kwangsiensis)的根茎进行化学成分研究。方法:运用硅胶、Sephadex LH-20柱色谱、ODS柱色谱和制备HPLC等分离手段进行化学成分的分离纯化,根据其波谱数据鉴定其结构。结果:从广西莪术中分离得到 7个化合物,分别鉴定为:[4-(1′-hydroxy-1′-methylethyl) benzoate-1′-O-β-D-glucopyranoside](1),[4-(1′-hydroxy-1′-methylethyl) ben-zoic acid-1′-O-β-D-glucopyranoside](2),2, 3,5-trihydroxy-1-(3-methoxy-4-hydroxyphenyl)-7-(3,5-dimethoxy-4-hydroxyphenyl) hep-tane(3) and 2,3, 5-trihydroxy-1-(4-hydroxyphenyl)-7-(3,5-dimethoxy-4-hydroxyphenyl)heptane(4),以及 1,5-epoxy-3α-hydroxy- 1-(3,4-dihydrox... 更多还原
【Abstract】 AIM:To study the bioactive constituents of Curcuma kwangsiensis.METHODS:The compounds were isolated by silica gel,Sephadex LH-20,and Rp-18 gel column chromatography,and preparative HPLC.The structures were elucidated by extensive spectroscopic methods including 2D-NMR and HRESI-MS.RESULTS:Four new compounds,methyl p-(1-β-D-glucopyranosy-loxy-1-methylethyl) benzoate(1),p-(1-β-D-glucopyranosyloxy-1-methylethyl) benzoic acid(2),2,3,5-trihydroxy-1-(3-methoxy-4-hydroxyphenyl)-7-(3,5-dimethoxy-4-hydro... 更多还原 【关键词】 广西莪术; 化学成分; 二苯庚烷类; 一氧化氮; 巨噬细胞; 【Key words】 Curcuma kwangsiensis; Chemical constituents; Diarylheptanoid; NO; Macrophages; 【基金】 supported by National Key Science and Technology Special Project (No. 2009ZX09301-012);Program for Liaoning Excellent Talents in University (No.LR201037)~~【分类号】R284.1
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