远志中的三萜皂苷和寡糖多酯类成分(英文) Triterpenoid Saponins and Oligosaccharides from the Roots of Polygala tenuifolia Willd 中国天然药物 , Chinese Journal of Natural Medicines, 编辑部邮箱 , 2011年05期 【作者】 李创军; 杨敬芝; 庾石山; 张东明; 薛微; 苑玉和; 陈乃宏;
【Author】 LI Chuang-Jun, YANG Jing-Zhi, YU Shi-Shan, ZHANG Dong-Ming*, XUE Wei, YUAN Yu-He, CHEN Nai-HongState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
【机构】 中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室;
【摘要】 目的:研究远志的抗老年痴呆活性成分。方法:采用活性追踪的方法,利用硅胶柱层析、反相中压色谱、制备高效液相等多种色谱技术分离单体化合物;并利用多种光谱技术确定化合物的结构。结果:从远志的根中分离得到了5个三萜皂苷类化合物Onjisaponin Wg(1),Fg(2),Ng(3),R(4)和O(5)及6个寡糖多酯类化合物tenuifolioses A(6),B(7),C(8),I(9),K(10),和G(11)。结论:化合物1为新化合物,化合物2-5首次报道其核磁数据;化合物6和7显示了PC12细胞的保护作用;化合物7和8可增强大鼠齿状回突触的传递作用,表明具有改善大鼠学习记忆的活性。 更多还原
【Abstract】 AIM: To study the chemical constituents and bioactivities of the roots of Polygala tenuifolia Willd.. METHODS: Bioactivity-guide was applied to study the chemical constituents of P. tenuifolia, and the chemical structures were determined by application of spectroal data (NMR, MS). RESULTS: One new, four known triterpenoid saponins and six oligosaccharides were obtained and their structures were identified as 3-O-β-D-glucopyranosyl-presenegenin 28-O-α-L-arabinopyranosyl-(1→3)-β-D-xylopyranosyl-(1... 更多还原 【关键词】 远志; 三萜皂苷; 寡糖多酯; 神经细胞(PC12细胞)保护; 突触传递; 【Key words】 Polygala tenuifolia Willd.; Triterpenoid saponin; Onjisaponin Wg: Oligosaccharide; Neuroprotection; 【基金】 supported by the National Natural Science Foundation of China (Nos. 20372087 and 81073078)~~【分类号】R284.1
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