| 陈 锋1，朱震宏2，刘素辉1，顾丹今1，陈 坚3，孙玉萍1 蒜氨酸、蒜酶及二者联用对耐甲氧西林金黄色葡萄球菌的抗菌作用 |
| 论文编辑部-新丝路理论网 2011-03-31 15:36:47 作者:中华医学之家：http://www.xinxi85.com 来源: 文字大小:[大][中][小] |
|
Title:
In vitro antibacterial effects of alliin, alliinase and alliin+alliinase against methicillin-resistant Staphylococcus aureus
- 文章编号:
- 1617-8259(2011)02-0190-03
- 作者:
- 陈 锋1; 朱震宏2; 刘素辉1; 顾丹今1; 陈 坚3; 孙玉萍1
- 新疆医科大学：1. 基础医学院；2. 第一附属医院检验科；3. 药学院，新疆乌鲁木齐 830054
- Author(s):
- CHEN Feng1; ZHU Zhen-hong2; LIU Su-hui1; GU Dan-jin1; CHEN Jian3; SUN Yu-ping1
- 1. College of Basic Medicine; 2. Department of Clinical Laboratory, the First Affiliated Hospital; 3. College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China
- 关键词:
- ; 蒜氨酸; 蒜酶; 耐甲氧西林金黄色葡萄球菌; 最小抑菌浓度; 最小杀菌浓度; 时间-杀伤曲线
- Keywords:
- ; alliin; alliinase; methicillin-resistant Staphylococcus aureus (MRSA); minimal inhibitory concentration (MIC); minimal bactericidal concentration (MBC); time-killing curve
- 分类号:
- R37
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 摘要：目的 了解蒜氨酸、蒜酶及蒜氨酸+蒜酶对耐甲氧西林金黄色葡萄球菌(MRSA)的体外抗菌活性。方法 采用液体稀释法、平板计数法检测蒜氨酸、蒜酶及蒜氨酸+蒜酶对10株临床分离的MRSA体外抗菌活性，并采用菌落法绘制时间-杀伤曲线。结果 蒜氨酸和蒜氨酸+蒜酶均对MRSA有抗菌活性，而蒜酶无作用。结论 蒜氨酸和蒜氨酸+蒜酶均为对MRSA敏感的抗菌药物，有望用于治疗由MRSA引起的感染性疾病。
- Abstract:
- ABSTRACT: Objective To investigate in vitro antibacterial effects of alliin, alliinase and alliin+alliinase against methicillin-resistant Staphylococcus aureus (MRSA). Methods Broth dilution and agar count methods were used to determine in vitro antibacterial effects of alliin, alliinase and alliin+alliinase against 10 clinically isolated MRSA strains. Time killing curves were drawn. Results Alliin and alliin+alliinase showed antimicrobial activities against MRSA, but alliinase could not inhibit their growth. Conclusion Both alliin and alliin + alliinase are antimicrobial drugs sensitive to MRSA and thus have the prospect of treating infectious diseases caused by MRSA.
参考文献/References
[1]BLOCK E. The organosulfur chemistry of the genus Allium-implications for the organic chemistry of sulfur [J]. Angew Chem Int Ed Engl, 1992, 31(9):1135-1178.
[2]李明远. 微生物学与免疫学 [M]. 北京: 人民卫生出版社,2002:84-126.
[3]周邦靖. 常用中药的抗菌作用及其测定方法 [M]. 重庆:科学技术文献出版社重庆分社, 1987:1-36.
[4]CHRISTENSEN KJ, GUBBINS PO. Treatment of vancomycin-resistant staphylococcal infection [J]. J Ann Pharmacotherapy, 1996, 30(3):288- 291.
[5]TENOVER FC. Implacations of vancomycin-resistant Staphylococcus aureus [J]. J Hosp Infect, 1999, 43(Suppl):s3-s7.
[6]CUTLER RR, WILSON P. Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus [J]. Br J Biomed Sci, 2004, 61(2):1-4.
中华医学之家：http://www.xinxi85.com
投稿信箱：zhyxzj85@163.com
联系电话：029--85327298 主编QQ：693891972 |
|
|
|
|
百度百科
