论文编辑部-新丝路理论网_吴娜，郑焱，郗彦萍TLR2 mRNA和TLR4 mRNA在银屑病皮损中的表达

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吴娜，郑焱，郗彦萍TLR2 mRNA和TLR4 mRNA在银屑病皮损中的表达

论文编辑部-新丝路理论网 2011-03-31 16:01:47 作者:中华医学之家：http://www.xinxi85.com 来源: 文字大小:[大][中][小]

Title:

Expression of TLR2 mRNA and TLR4 mRNA in psoriatic lesions

文章编号:: 1671-8259(2011)02-0250-03

作者:: 吴娜; 郑焱; 郗彦萍; 西安交通大学医学院第二附属医院皮肤科，陕西西安 710004

Author(s):: WU Na; ZHENG Yan; XI Yan-ping; Department of Dermatology, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710004, China

关键词:: ; 银屑病; Toll样受体2; Toll样受体4

Keywords:: ; psoriasis; toll-like receptor 2 (TLR2); toll-like receptor 4 (TLR4)

分类号:: R758.63

DOI:: -

文献标识码:: A

摘要:: 摘要：目的 探讨Toll样受体2(TLR2)mRNA和Toll样受体4(TLR4)mRNA在银屑病皮损中表达的变化。方法采用原位杂交技术检测银屑病皮损处和正常皮肤中TLR2 mRNA和TLR4m RNA的表达情况。结果寻常型银屑病皮损中TLR2 mRNA和TLR4 mRNA主要表达于表皮基底上层；正常皮肤则表达于表皮的基底层。统计学分析表明，TLR2 mRNA和TLR4 mRNA在正常皮肤和银屑病皮损处基底层和基底上层的表达差异均有统计学意义(P<0.05)，且TLR2 mRNA和TLR4 mRNA在银屑病皮损中的表达均高于正常皮肤组织(P<0.05)。结论 TLR2和TLR4可能在银屑病的发生与发展过程中发挥重要的作用。

Abstract:: ABSTRACT: Objective To detect the expression of toll-like receptor 2 (TLR2) mRNA and toll-like receptor 4 (TLR4) mRNA in psoriatic skin lesions. Methods By using in situ hybridization, TLR2 mRNA and TLR4 mRNA expression levels were detected in psoriatic lesional and normal skin tissues. Results TLR2 mRNA and TLR4 mRNA were highly expressed in the suprabasal layer of psoriatic lesions, while in normal epidermis TLR2 mRNA and TLR4 mRNA were expressed in the basal layer of epidermis. There was a significant difference between psoriatic lesion and the normal epiderm (P<0.05), and TLR2 mRNA and TLR4 mRNA expressions were higher in psoriatic lesional epidermis than in the normal epidermis. Conclusion TLR2 and TLR4 may play a crucial role in the pathogenesis and development of psoriasis.

参考文献/References

[1]MCINTURFF JE, MODLIN RL, KIM J. The role of toll-like receptors in the pathogenesis and treatment of dermatological disease [J]. J Invest Dermatol, 2005, 125(1):1-8.
[2]LLOYD SM. Toll-like receptors in skin [J]. Adv Dermatol, 2008, 24(9):71-87.
[3]GABRIELE K, BEHNAM NK, VERENA V, et al. Various members of the toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes [J]. Immunology, 2005, 114(4):531-541.
[4]LLOYD SM, OLE ES, PHILIP TL, et al. TGF-a regulates TLR expression and function on epidermal keratinocytes [J]. J Immunol, 2005, 174(10):6137-6143.
[5]BEGON E, MICHEL L, FLAGEUL B, et al. Expression, subcellular localization andcytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin [J]. Eur J Dermatol, 2007, 17(6):497-506.
[6]BAKER BS, OVIGNE JM, POWLES AV, et al. Normal keratinocyte express toll-like receptors (TLRs) 1, 2 and 5 modulation of TLR expression in chronic plaque psoriasis [J]. Br J Dermatol, 2003, 148(4):670-679.
[7]CURRY JL, QIN JZ, BONISH B, et al. Innate immune-related receptors in normal and psoriatic skin [J]. Arch Pathol Lab Med, 2003, 127(2):178-186.

基金项目：国家自然科学基金资助项目(No.30872265；No.81071299)
Supported by the National Natural Science Foundation of China (No.30872265；No.81071299)
通讯作者：郑焱，副研究员，硕士生导师. E-mail: zenyan66@126.com
作者简介：吴娜(1982-)，女(汉族)，硕士研究生. 研究方向：银屑病的发病机制. E-mail: wsabrina@163.com

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