| 丁 丽1，郭 炫1，张志峰2，赵 珊1非高密度脂蛋白胆固醇与2型糖尿病的相关性 |
| 论文编辑部-新丝路理论网 2011-03-31 16:07:17 作者:中华医学之家：http://www.xinxi85.com 来源: 文字大小:[大][中][小] |
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Title:
Correlation between non-high density lipoprotein cholesterol level and type 2 diabetes mellitus
- 文章编号:
- 1671-8259(2011)02-0261-03
- 作者:
- 丁 丽1; 郭 炫1; 张志峰2; 赵 珊1
- 西安交通大学医学院：1. 第一附属医院检验科；2. 卫生系营养与食品卫生学教研室，陕西西安 710061
- Author(s):
- DING Li1; GUO Xuan1; ZHANG Zhi-feng2; ZHAO Shan1
- 1. Clinical Laboratory, the First Affiliated Hospital; 2. Teaching and Research Section of Nutrition and Food, Medical School of Xi’an Jiaotong University, Xi’an 710061, China
- 关键词:
- ; 非高密度脂蛋白胆固醇; 2型糖尿病; 总胆固醇; 甘油三酯
- Keywords:
- ; non-high density lipoprotein cholesterol; type 2 diabetes mellitus; total cholesterol; triglyceride
- 分类号:
- R543.5
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 摘要：目的 探讨非高密度脂蛋白胆固醇(non-HDL-C)水平与2型糖尿病(DM)的相关性。方法 选取180例2型DM患者为DM实验组，经健康体检合格者100例为正常对照组。DM实验组又按照有无合并其他脏器病变分为Ⅰ、Ⅱ、Ⅲ级，Ⅰ级：单纯2型DM组；Ⅱ级：2型DM合并有排除冠状动脉疾病(CAD)的其他脏器并发症组；Ⅲ级：2型DM合并冠状动脉疾病(CAD)。分别测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)，并计算出非高密度脂蛋白胆固醇(non-HDL-C)的含量。结果 DM实验组血清non-HDL-C明显高于正常对照组(P<0.05)，且DM实验组组间有统计学差异。Logistic回归分析显示，DM实验组血清non-HDL-C的OR值略强于TG，明显强于TC 和LDL-C，并随着合并症的不同OR值优势显著。结论 血清non-HDL-C与2型DM不同的合并症发展进程有正相关性，且相关性优于TG、TC和LDL-C。
- Abstract:
- ABSTRACT: Objective To explore the correlation between non-high density lipoprotein cholesterol (non-HDL-C) level and type 2 diabetes mellitus (DM). Methods We selected 180 patients with type 2 diabetes as the experimental group and 100 persons who passed the physical check-up served as normal controls. According to complications involving other organs, patients in the experimental group were divided into Grade Ⅰ, Ⅱ and Ⅲ groups. Grade Ⅰ: simple type 2 DM; Grade Ⅱ: type 2 DM with complications involving other organs excluding coronary artery disease (CAD); Grade Ⅲ: type 2 DM complicated with CAD. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured; non-HDL-C level was calculated. Results Serum non-HDL-C level was significantly higher in DM group than in control group (P<0.05), and in the experimental group significant differences existed among different sub-groups. Logistic regression analysis showed that in the experimental group OR of serum non-HDL-C was slightly greater than that of TG and obviously stronger than that of TC and LDL-C; OR value had a significant advantage when complications differed. Conclusion Serum non-HDL-C has a positive correlation with different complication development stages of type 2 DM, and the correlation is greater than with TG, TC and LDL-C.
参考文献/References
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