血管内皮生长因子C和趋化因子受体CCR7的表达与膀胱癌淋巴结转移之间的关系 Correlation of vascular endothelial growth factor C and chemokine receptor CCR7 with lymph node metastasis in bladder cancer推荐 CAJ下载 PDF下载 不支持迅雷等下载工具,请取消加速工具后下载。
解剖科学进展 , Progress of Anatomical Sciences, 编辑部邮箱 , 2011年05期 【作者】 黄启成; 李鑫磊; 杨树才; 孔建; 马晶;
【Author】 HUANG Qi-cheng1,2, LI Xin-lei1, YANG Shu-cai1, KONG Jian1, MA Jing1* (1.Department of Anatomy, Harbin Medical University, Harbin 150081; 2. The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000 China)
【机构】 哈尔滨医科大学解剖教研室; 齐齐哈尔医学院附属第三医院;
【摘要】 目的观察血管内皮生长因子(VEGF)-C和趋化因子受体CCR7在膀胱移行细胞癌组织内的表达情况,分析VEGF-C和CCR7表达与癌淋巴结转移之间的关系。方法取膀胱癌病例60例,其中,淋巴结转移组36例,无淋巴结转移组24例。应用免疫组化法和Western blot技术观察VEGF-C和CCR7在膀胱癌组织内的表达。结果 VEGF-C和CCR7主要表达于膀胱癌细胞胞浆或/和胞膜内,二者在淋巴结转移组的表达率明显高于无淋巴结转移组。VEGF-C和CCR7蛋白同时表达在淋巴结转移组和非淋巴结转移组中的表达率分别为61.1%和33.3%,VEGF-C和CCR7的表达具有显著的相关性,联合检测VEGF-C和CCR7诊断膀胱癌淋巴结转移具有较高的准确度,ROC曲线下面积达0.708。结论 VEGF-C和CCR7在促进膀胱癌淋巴结转移中可能具有一定的协同作用,二者联合检测有助于膀胱癌淋巴结转移的早期诊断 更多还原
【Abstract】 Objective To investigate the effects of vascular endothelial growth factor (VEGF)-C and CCR7 in lymph node metastasis, the expression of VEGF-C and CCR7 was observed in bladder cancer. Methods Sixty paraffin-embedded specimens from patients with bladder cancer were devided into lymph node metastasis group(n=36) and nonmetastasis group(n=24). The expressions of VEGF-C and CCR7 were detected by immunohistochemical stain and Western blot. Results VEGF-C and CCR7 proteins were expressed predominantl... 更多还原 【关键词】 VEGF-C; CCR7; 淋巴结转移; 膀胱癌; 【Key words】 VEGF-C; CCR7; lymph node metastasis; bladder cancer; 【基金】 黑龙江省自然科学基金资助项目(No.D201041)【分类号】R737.14
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