采用UPLC-Q-TOF/MS~E鉴别芪苈强心胶囊有效部位中的化学成分 Identification of chemical constituents in Qiliqiangxin capsule by UPLC-Q-TOF/MSE推荐 CAJ下载 PDF下载 不支持迅雷等下载工具,请取消加速工具后下载。
药学学报 , Acta Pharmaceutica Sinica, 编辑部邮箱 , 2011年10期 【作者】 康利平; 赵阳; 余河水; 刘奕训; 熊呈琦; 谭大维; 贾继明; 王宏涛; 田书彦; 马百平;
【Author】 KANG Li-ping1,ZHAO Yang1,YU He-shui1,LIU Yi-xun1,XIONG Cheng-qi1,TAN Da-wei1, JIA Ji-ming2,WANG Hong-tao2,TIAN Shu-yan2,MA Bai-ping1(1.Beijing Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China; 2.Hebei Yiling Medicine Institute,Shijiazhuang 050035,China)
【机构】 军事医学科学院放射与辐射医学研究所; 河北以岭医药研究院;
【摘要】 为了全面快速地阐明复方中药芪苈强心胶囊的化学组成,本文利用UPLC-Q-TOF/MSE对芪苈强心胶囊进行了快速分析和成分鉴定,从芪苈强心胶囊中鉴定了40个化合物,并归属了各化合物的单味药来源。结果显示,芪苈强心胶囊的主要成分包括三萜皂苷类、黄酮苷类、C21甾类和酚酸类等。该研究比较全面地阐明了芪苈强心胶囊的化学组成,为此中药复方制剂的质量控制和物质基础研究奠定了基础。 更多还原
【Abstract】 In order to clarify the chemical constituents in Qiliqiangxin capsule,a rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry(UPLC-Q-TOF/MSE) method was established.Forty peaks were identified on line using this method.The herbal sources of these peaks were assigned.The results implied that triterpenoid saponins,flavonoid glycosides,C21-steroids and phenolic acids were included in the main components of Qiliqiangxin capsule.The method is simple an... 更多还原 【关键词】 芪苈强心胶囊; UPLC-Q-TOF/MSE; 三萜皂苷; 【Key words】 Qiliqiangxin capsule; UPLC-Q-TOF/MSE; triterpenoid saponin; 【基金】 国家科技支撑计划资助项目(2006BAI08B04-09);国家重点基础研究发展计划(973计划)资助项目(2005CB523301)【分类号】R286.0
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