【作者】 袁婷婷; 吴波; 邹晓毅;
【Author】 YUAN Ting-ting,WU Bo,ZOU Xiao-yi Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China
【机构】 四川大学华西医院神经内科;
【摘要】 目的系统评价普罗加比(progabide,PGB)治疗难治性癫痫的有效性及安全性。方法计算机检索PubMed、EMbase、e Cochrane Central Register of Controlled Trial(s CENTRAL)、CNKI、VIP和CBM等电子数据库,查找PGB治疗难治性癫痫的随机对照试验(RCT),检索时间均从建库至2011年7月。对符合纳入标准的RCT,由两位评价员按Cochrane系统评价的方法,独立进行资料提取、质量评价并交叉核对后,采用RevMan 5.1软件进行Meta分析。结果共纳入7个研究,合计231例患者。Meta分析结果显示,在常规治疗基础上,与安慰剂相比,PGB对单纯难治性部分性癫痫无效[OR=1.76,95%CI(0.40,7.65),P=0.45];对难治性部分性+全面性癫痫的有效率高于安慰剂组[OR=4.46,95%CI(2.06,9.65),P=0.000 1]。PGB的主要不良反应为嗜睡、头晕、头痛等,但表现多轻微、短暂,减少剂量多可恢复正常,仅少数患者需停药。结论现有研究证据显示,PGB可能对难治性部分性+全面性癫痫具有较好... 更多还原
【Abstract】 Objective To assess the effectiveness and safety of progabide(PGB) for refractory epilepsy.Methods Randomized controlled trials(RCTs) on PGB treating refractory epilepsy were searched from the following databases as PubMed,EMbase,The Cochrane Library,CNKI,CBM and VIP from the date of their establishment to July 2011.The data of RCTs meeting the inclusive criteria were extracted according to Cochrane methods by two reviewers independently,and after the quality was evaluated and cross-checked,meta... 更多还原 【关键词】 普罗加比; 难治性癫痫; Meta分析; 系统评价; 随机对照试验; 【Key words】 Progabide; Refractory epilepsy; Meta-analysis; Systematic review; Randomized controlled trial; 【基金】 四川省医学会基金(编号:SHD11-09) 【分类号】R742.1
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